Evaluation of therapeutic role of zinc oxide nanoparticles on dextran sulfate sodium salt

Evaluation of therapeutic role of zinc oxide nanoparticles on dextran sulfate sodium salt

2018/6/11 17:11:38

This study designed to investigate the anti -inflammatory effect of zinc oxide nanoparticles (ZnONPs) on inflammatory mediators in dextran sulfate sodium salt induced ulcerative colitis(UC) in rats .twinty -four albino rats divided into 4 equal of eight rats each. Group 1: (normal control) received no drugs , group 2: (ulcerative colitis) rats received dextran sulfate sodium salt 3% in drinking water, group 3: (ZnONPs) rats administered ZnONPs (5mg/kg body weight) orally for 3weeks, group 4: (ZnONPs +UC) rats with ulcerative colitis orally treated with ZnONPs (5mg/kg body weight) daily for 3 weeks . The obtained results revealed that administration of ZnONPs to rats with ulcerative colitis have no change on serum total cholesterol and TG concentrations and markedly increased the reduced HDL-C level . On the other hand, elevated level of COX-2, IL-6, MDA and TNF-伪 in UC rats were significantly reduced, with significant increase of the reduced level of GSH. Results suggest that ZnONPs modulates UC.