2018/6/11 17:10:17
This study designed to investigate the anti-inflammatory effect of aloe component (aloin) on inflammatory mediators and oxidative stress in dextran sulfate sodium salt induced ulcerative colitis (UC) in rats. Twenty-four albino rats divided into four equal groups of eight rats each. Group 1: (normal control) received no drugs , group 2: (ulcerative colitis) rats received dextran sulfate sodium salt 3% in drinking water, group 3: (aloin) rats administered orally with 1ml of a loin 0.1% daily for 3weeks, group 4: (aloin +UC) rats with ulcerative colitis orally treated with (aloin 0.1%), daily for 3weeks . The obtained results revealed that, administration of aloin to rats with ulcerative colitis showed non-significant change on serum total cholesterol and TG concentrations, and markedly increased the reduced HDL-C level. On the other hand, elevated level of COX-2, IL-6, MDA and TNF-伪 in UC rats were significantly reduced, with significant increase of the reduced level of GSH. Results revealed that aloin showed high efficacy to normalize UC tissues and may considered as potential treatment for UC and other inflammatory bowel disease.