2021/10/29 11:46:21
The application of Dextran sulfate sodium salt
The small molecular weight Dextran sulfate salt has a similar effect to the medium molecular weight and the low molecular dixtran sulfate sodium salt, with a shorter duration of action. The medium molecular weight Dextran sulfate salt, after intravenous injection, the concentration in the blood in the first 3 to 4 hours rapidly decreased, after a slow decline, 24 hours later has been reduced to 50% of the injection volume, 3 to 4 days there are 50 to 70% self-excretion. The expansion of blood capacity of this product, about 12 hours. Low molecular weight and small molecular weight Dextran sulfate sodium salt, due to the small molecular weight, stay in the body is also short, easy to excrete from the kidneys, its role in expanding blood volume is short, small molecular weight Dextran sulfate saltodium action maintenance time is only about 3 hours.
Dextran sulfate sodium salt is commonly used for first aid such as acute hemorrhage shock, traumatic shock and burn shock. The medium molecular weight Dextran sulfate sodium salt expands blood volume for a longer period of time. Low molecular weight and small molecular weight Dextran sulfate sodium salt are better for improving microcirculation. Common amount, 500 ml (medium molecule) or 250 to 500 ml (low molecule) intravenous drip at a time.
Dextran sulfate sodium salt accelerates the metabolism of VLDL and TG, and also competitively inhibits oxidation of LDL binding to macrophage receptors, preventing foam cell formation and the development of atherosclerosis lesions.